Impact combines academic, translational and institutional outputs across scientific programs, training, collaborations and evidence generation.

• Scientific publications.
• Grants and funded projects.
• Patents and intellectual property.
• Clinical cohorts and validation studies.
• Workshops and training programs.
• Industry and academic collaborations.
• Centres, networks and standards-building activity.

Articles, book chapters and patent information supplied for AHERF-CMBRC. Bibliographic details are presented as provided.

Articles

2026

1. Ganji, P., Bendre, R. V., Ghosh, A., Prabhakar, S., & Manda, S. V. (2026). A combined neuronal extracellular vesicle-haematology panel for clinical stratification of Alzheimer’s disease and dementia. Metabolic Brain Disease, 41(1), 120.
2. Patnam, S., Koppula, A., Kumar, S. K., Thalakanti, S., Bendre, R. V., Addla, S., & Manda, S. V. (2026). A multi-gene urinary extracellular vesicle mRNA panel as a non-invasive biomarkers for prostate cancer detection. Scientific Reports, 16(1), 18288.
3. Kumar, S. K., Thalakanti, S., Sreekanth, P., Kannaparthi, N., & Sasidhar, M. V. (2026). Exosomal MicroRNAs in Cancer: Bridging Mechanistic Insights with Biomarker Potential. In MicroRNAs: Role in Cancer Progression, Diagnostics and Therapy (pp. 551-577). Cham: Springer Nature Switzerland.

2025

1. Sarwareddy, K. K., Singh, A. D., Patnam, S., Sesuraj, B. A., Ponamgi, spd, Thakur, B. K., & Manda, V. S. (2025). Harnessing tomato-derived small extracellular vesicles as drug delivery system for cancer therapy. Future Science OA, 11(1). https://doi.org/10.1080/20565623.2025.2461956
2. Kumar, S. K., Kanaparthi, N., Annes, S. B., Bendre, R. V., Balakrishna, N., Kumar, S., ... & Sasidhar, M. V. (2025). Evaluation of salivary and serum Exosomal mRNAs as biomarkers for the diagnosis and prognosis of oral squamous cell carcinoma. Scientific Reports, 15(1), 38310.
3. Praveena, G., Jayachandran, A., Venkata, S. M., & Asthana, A. (2025). From bench to bedside: The evolution of extracellular vesicle diagnostics through microfluidic and paper-based technologies. Colloids and Surfaces B: Biointerfaces, 252, 114675.
4. Bharti, P. S., Rani, K., Singh, R., Rai, S., Rastogi, S., Batra, M., ... & Kumar, S. (2025). A simplified and efficient method for isolating small extracellular vesicles for comparative and comprehensive translational research. Scientific Reports, 15(1), 16367.
5. Patnam, S., Singh, A. D., Ali, M. S., Thakur, B. K., Rengan, A. K., & Manda, S. V. (2025). Development and in vitro characterization of Milk-Derived extracellular Vesicle-Mithramycin formulations for potential glioma therapy. Molecular Pharmaceutics, 22(6), 2881-2894.

2024

1. Praveena, G., Tummala, A., Kandadai, R. M., Yareeda, S., Nagaraju, V., Natarajan, V., ... & Manda, S. V. (2024). Establishment of Neurofilament Light Chain in Plasma-Derived Neuronal Extracellular Vesicles as a Biomarker for Disease Progression in Multiple Sclerosis Patients. Neurochemical Journal, 18(3), 527-537.
2. Ganji, P., Prabhakar, S., & Manda, S. V. (2024). Therapeutic Role of Extracellular Vesicles in Neurodegenerative Disorders. In Extracellular Vesicles in Human Health and Diseases (pp. 289-312). Singapore: Springer Nature Singapore.
3. Kumar, S. K., Sathrasala, S., Krishna, J. S., Sreekanth, P., Singh, A. D., Ratnamani, M. S., ... & Kuragayala, S. D. (2024). Vaccine-elicited immune pressure and SARS-CoV-2 mutational dynamics in breakthrough infections. Gene Reports, 35, 101899.
4. Velugonda, N., Patchva, D., Manda, S. V., & Gundeti, S. (2024). In vitro cytotoxicity analysis on patient-derived PBMCs to predict 6-mercaptopurine therapy response in children with acute lymphoblastic leukemia. Indian Journal of Biochemistry and Biophysics (IJBB), 61(6), 371-379.
5. Patnam, S., Majumder, B., Joshi, P., Singh, A. D., Nagalla, B., Kumar, D., ... & Manda, S. V. (2024). Differential Expression of SRY-Related HMG-Box Transcription Factor 2, Oligodendrocyte Lineage Transcription Factor 2, and Zinc Finger E-Box Binding Homeobox 1 in Serum-Derived Extracellular Vesicles: Implications for Mithramycin Sensitivity and Targeted Therapy in High-Grade Glioma. ACS Pharmacology & Translational Science, 7(1), 137-149.
6. Manda, S., & Sawareddy, K. (2024). From fluids to forecasts: the promise of small extracellular vesicle MiRNAs in revolutionising cancer diagnostics. Beyond the Blueprint-Decoding the Elegance of Gene Expression, 1-22.

2023

1. Singh, A. D., Patnam, S., Manocha, A., Bashyam, L., Rengan, A. K., & Sasidhar, M. V. (2023). Polyethylene glycol-based isolation of urinary extracellular vesicles, an easily adoptable protocol. MethodsX, 11, 102310.
2. Singh, A. D., Nagalla, B., Patnam, S., Satyanaryana, G., Andrews, R., Panigrahi, A. K., ... & Sasidhar, M. V. (2023). Exploring urinary extracellular vesicles for organ transplant monitoring: A comprehensive study for detection of allograft dysfunction using immune-specific markers. Clinica Chimica Acta, 548, 117525.
3. Kumar, S. K., & Sasidhar, M. V. (2023). Recent trends in the use of small extracellular vesicles as optimal drug delivery vehicles in oncology. Molecular Pharmaceutics, 20(8), 3829-3842.
4. Patnam, S., Ranganathan, S., Balakrishna, N., Singh, A. D., Koyyada, R., Kuragayala, S. D., ... & Rao, P. V. (2023). Association between ABO blood groups and their clinical indices during COVID-19 infection. Asian Journal of Transfusion Science, 19(1), 85.

2022

1. Singh, A. D., Patnam, S., Koyyada, R., Samal, R., Alvi, S. B., Satyanaryana, G., ... & Sasidhar, M. V. (2022). Identifying stable reference genes in polyethene glycol precipitated urinary extracellular vesicles for RT-qPCR-based gene expression studies in renal graft dysfunction patients. Transplant Immunology, 75, 101715.
2. Singh, A. D., Patnam, S., Rengan, A. K., & Manda, S. V. (2022, November). Immunomodulatory Roles of Extracellular Vesicles Secreted from Human Umbilical Cord-Derived Mesenchymal Stem Cells. In 2022 E-Health and Bioengineering Conference (EHB) (pp. 1-4). IEEE.
3. Koyyada, R., Nagalla, B., Tummala, A., Singh, A. D., Patnam, S., Barigala, R., ... & Manda, S. V. (2022). Prevalence and impact of preexisting comorbidities on overall clinical outcomes of hospitalized COVID-19 patients. BioMed Research International, 2022(1), 2349890.
4. Tummala, A., Ramesh, V., Balakrishna, N., Koyyada, R., Singh, A. D., Patnam, S., ... & Narreddy, S. (2022). Diagnostic Values of Laboratory Biomarkers in Predicting a Severe Course of COVID-19 on Hospital Admission. BioMed Research International, 2022(1), 5644956.
5. Patnam, S., Samal, R., Koyyada, R., Joshi, P., Singh, A. D., Nagalla, B., ... & Manda, S. V. (2022). Exosomal PTEN as a predictive marker of aggressive gliomas. Neurology India, 70(1), 215-222.

2021

1. Singh, A. D., Koyyada, R., Samal, R., Alvi, S. B., Patnam, S., Rengan, A. K., ... & Manda, S. V. (2021). Establishment of Optimal Housekeeping Genes for Urinary Extracellular Vesicle Biomarker Development: A Step towards Non-invasive Diagnostics.
2. Singh, A. D. (2021). Bovine milk derived exosomal-curcumin exhibiting enhanced stability, solubility, and cellular bioavailability. Clinics in Oncology.

2018

1. Jayachandran, A., Manda, S. V., Shrestha, R., Bridle, K. R., Prithviraj, P., & Crawford, D. H. (2018). Exosome-based liquid biopsy in the management of hepatocellular carcinoma. Hepatoma Research, 4, N-A.
2. Singh, S. P., Alvi, S. B., Pemmaraju, D. B., Singh, A. D., Manda, S. V., Srivastava, R., & Rengan, A. K. (2018). NIR triggered liposome gold nanoparticles entrapping curcumin as in situ adjuvant for photothermal treatment of skin cancer. International Journal of Biological Macromolecules, 110, 375-382.

2017

1. Sasidhar, M. V., Chevooru, S. K., Eickelberg, O., Hartung, H. P., & Neuhaus, O. (2017). Downregulation of monocytic differentiation via modulation of CD147 by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. PLoS One, 12(12), e0189701.
2. Manda, S. V., Kataria, Y., Tatireddy, B. R., Ramakrishnan, B., Ratnam, B. G., Lath, R., ... & Ray, A. (2017). Exosomes as a biomarker platform for detecting epidermal growth factor receptor-positive high-grade gliomas. Journal of Neurosurgery, 128(4), 1091-1101.
3. Medapati, M. R., Singh, A., Korupally, R. R., Henderson, D., Klonisch, T., Manda, S. V., & Chelikani, P. (2017). Characterization of GPCRs in extracellular vesicle (EV). In Methods in Cell Biology (Vol. 142, pp. 119-132). Academic Press.

2015

1. Manda, S. V., Tatireddy, B. R., Kataria, Y., Ranjan, A., & Ray, A. (2015). CBM-11 Exosomal and clinical analysis of EGFR amplification and EGFRvIII expression in Indian glioma patients. Neuro-Oncology, 17(suppl_5), v71-v71.
2. Rath, P. C., Chidambaram, S., Rath, P., Dikshit, B., Naik, S., Sahoo, P. K., ... & Jain, J. (2015). A study on the impact of CYP2C19 genotype and platelet reactivity assay on patients undergoing PCI. Indian Heart Journal, 67(2), 114-121.

2014

1. Sasidhar, M. V., Reddy, S., Naik, A., & Naik, S. (2014). Genetics of coronary artery disease-A clinician's perspective. Indian Heart Journal, 66(6), 663-671.

Book Chapters

1. Pathak, Surajit, and Antara Banerjee. MicroRNAs: Role in Cancer Progression, Diagnostics and Therapy. Springer, 2026.
2. Ganji, P., Hanagodu, M., Rao, P. G., Varigonda, D., Prabhakar, S., & Venkata, S. M. (2026). Mesenchymal stem cells and extracellular vesicles in neurodegenerative diseases. In Mesenchymal Stem Cells and Extracellular Vesicles as Next-Generation Therapeutics (pp. 231-270). Academic Press.
3. Jayachandran, A., Kotkar, A., Praveena, G., Chandankar, S., Venkata, S. M., & Asthana, A. (2026). Microfluidics in mesenchymal stem cell and extracellular vesicle research. In Mesenchymal Stem Cells and Extracellular Vesicles as Next-Generation Therapeutics (pp. 663-693). Academic Press.
4. Kumar, S. K., Praveena, G., Sreekanth, P., Maitra, S., & Manda, S. V. (2026). Extracellular vesicles in the diagnosis of diabetes mellitus and associated complications. Extracellular Vesicle-Based Biovectors for Diagnostic and Biomedical Applications, 363-388.
5. Kartik Kumar, S., and Venkata Sasidhar. M. From Fluids to Forecasts: The Promise of Small Extracellular Vesicle miRNAs in Revolutionising Cancer Diagnostics. In Beyond the Blueprint-Decoding the Elegance of Gene Expression (2024). IntechOpen: London, UK.

Grant content demonstrates funder confidence, execution capability and translational relevance.

• Grant title.
• Funding agency.
• Role of AHERF-CMBRC.
• Scientific area.
• Translational outcome or expected deliverable.

1. Biomarker panels, systems, and methods for risk stratification of a subject for Alzheimer's disease. US20230340597A1

Collaborations span academic, industry, clinical, institutional and standards-linked networks.

• Academic collaborations.
• Industry partnerships.
• Clinical consortia.
• MoUs and institutional partnerships.
• Standards and society-linked activity.

Events and workshops show active capacity building and community leadership. Public AHERF material includes EV and exosome-focused training, including “From Sample - Signal: Exosome Diagnostic Workflows,” a 2026 workshop on EV-based liquid biopsy, isolation, multimodal characterization, nano-flow cytometry and digital PCR.

• Scientific conferences.
• Hands-on EV and liquid biopsy workshops.
• Digital PCR and multimodal characterization training.
• Standards and quality-focused sessions.
• Clinician-scientist engagement events.

Centres, networks and ecosystem-building initiatives reflect AHERF-CMBRC’s role in translational research, training and standards-oriented collaboration.

• EV ecosystem activities.
• Centre of Excellence activities.
• Clinical consortia.
• Standards and training networks.